PFIM - Population Fisher Information Matrix

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix; see <doi:10.1093/biomet/84.2.429> and <doi:10.1016/S0169-2607(00)00117-6>. Supports population, individual, and Bayesian 'FIMs', covariates, inter-occasion variability, and D-optimal search ('Fedorov-Wynn', multiplicative, simplex, 'PSO', 'PGBO').